Differential Plasma-cell evolution is linked with Dermatophagoides pteronyssinus immunotherapy response
نویسندگان
چکیده
منابع مشابه
Differential Plasma-cell evolution is linked with Dermatophagoides pteronyssinus immunotherapy response
Allergic rhinitis is highly prevalent worldwide. Immunotherapy has been shown to control its symptoms, however, up to 30% of patients may not respond. Previous studies of the immunological mechanisms involved in allergen-immunotherapy (AIT) have focused on the humoral and T-cell response and several studies have evaluated some B-cell subpopulations during AIT and their role in immunological tol...
متن کاملProteases of Dermatophagoides pteronyssinus
Since the discovery that Der p 1 is a cysteine protease, the role of proteolytic activity in allergic sensitization has been explored. There are many allergens with proteolytic activity; however, exposure from dust mites is not limited to allergens. In this paper, genomic, transcriptomic and proteomic data on Dermatophagoides pteronyssinus (DP) was mined for information regarding the complete d...
متن کاملRandomized dose-response study of subcutaneous immunotherapy with a Dermatophagoides pteronyssinus extract in patients with respiratory allergy.
AIM To evaluate the efficacy of Dermatophagoides pteronyssinus (DPT) subcutaneous immunotherapy in allergic rhinoconjunctivitis patients. PATIENTS & METHODS This 17-week double-blind study randomized 136 patients (95 evaluable) to five dose groups of DPT depot extract (0.0625-0.75 skin prick test [SPT] units) or placebo, administered in a six updosing schedule. RESULTS A dose-response was o...
متن کاملSubcutaneous allergen immunotherapy with dermatophagoides pteronyssinus in patient with local allergic rhinitis
Methods A randomized, double-blind, placebo-controled, parallelgroup, phase II study was conducted. Thirty-six subjects with LAR to DP were randomized to receive Pangraminâ PLUS, ALK, Dermatophagoides pteronyssinus (AIT-DP) or placebo for 24 months. The primary endpoint was total symptoms (TSS) and total medication scores (TMS). Secondary endpoints included: total combined symptom+medication sc...
متن کاملClinical changes induced by allergen immunotherapy with dermatophagoides pteronyssinus in local allergic rhinitis
Methods Thirty-six subjects with LAR to DP were selected to participate in a double-blind, placebo-controlled, parallelgroup, phase II clinical trial of subcutaneous AIT in LAR. The patients were randomized to receive AIT-DP with Pangramin PLUS, ALK, DP, or placebo for a period of 24 months. The primary endpoint was total symptoms (TSS) and total medication scores (TMS). Secondary endpoints wer...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2015
ISSN: 2045-2322
DOI: 10.1038/srep14482